Neuropharmacology of vision in goldfish: a review

Vision Res. 2009 May;49(9):960-9. doi: 10.1016/j.visres.2008.08.004. Epub 2008 Sep 27.

Abstract

The goldfish is one of the few animals exceptionally well analyzed in behavioral experiments and also in electrophysiological and neuroanatomical investigations of the retina. To get insight into the functional organization of the retina we studied color vision, motion detection and temporal resolution before and after intra-ocular injection of neuropharmaca with known effects on retinal neurons. Bicuculline, strychnine, curare, atropine, and dopamine D1- and D2-receptor antagonists were used. The results reviewed here indicate separate and parallel processing of L-cone contribution to different visual functions, and the influence of several neurotransmitters (dopamine, acetylcholine, glycine, and GABA) on motion vision, color vision, and temporal resolution.

MeSH terms

  • Acetylcholine / pharmacology
  • Animals
  • Color Vision / drug effects
  • Color Vision / physiology
  • Dopamine / pharmacology
  • Dose-Response Relationship, Drug
  • Electroretinography / drug effects
  • Glycine / pharmacology
  • Goldfish / physiology*
  • Motion Perception / drug effects
  • Motion Perception / physiology
  • Neurotransmitter Agents / pharmacology*
  • Retina / drug effects
  • Retina / physiology*
  • Time Perception / drug effects
  • Time Perception / physiology
  • Vision, Ocular / drug effects
  • Vision, Ocular / physiology*
  • gamma-Aminobutyric Acid / pharmacology

Substances

  • Neurotransmitter Agents
  • gamma-Aminobutyric Acid
  • Acetylcholine
  • Glycine
  • Dopamine