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Neuroreport. 2008 Sep 17;19(14):1361-4. doi: 10.1097/WNR.0b013e32830e6dd6.

Differential regulation of neurogenesis in two neurogenic regions of APPswe/PS1dE9 transgenic mice.

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  • 1Department of Neuroscience for Drug Discovery, Graduate School of Pharmaceutical Sciences, Kyoto University, Japan. tniidome@pharm.kyoto-u.ac.jp

Abstract

Neurogenesis occurs in two neurogenic regions of the adult mammalian brain: the subgranular zone and the subventricular zone. We have recently demonstrated that the number of bromodeoxyuridine-positive and doublecortin-positive cells is decreased in the subgranular zone of amyloid precursor protein with a Swedish mutation and presenilin-1 with a deletion of exon 9 transgenic mice, an animal model of Alzheimer's disease. In this study, we characterized neurogenesis in the subventricular zone of amyloid precursor protein with a Swedish mutation and presenilin-1 with a deletion of exon 9 transgenic mice at 9 months of age and compared it with neurogenesis in the subgranular zone. In the subventricular zone, the number of proliferating cell nuclear antigen-positive and bromodeoxyuridine-positive cells were normal. In the subgranular zone, the number of proliferating cell nuclear antigen-positive cells was normal; however, the number of bromodeoxyuridine-positive cells was significantly decreased. These results suggest that neurogenesis, probably reflecting the survival of neural progenitor cells, differs between the subgranular zone and the subventricular zone.

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