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Int J Biochem Cell Biol. 2009 Jan;41(1):16-20. doi: 10.1016/j.biocel.2008.07.020. Epub 2008 Aug 12.

Molecular basis of the anti-cancer effects of histone deacetylase inhibitors.

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Center for Biomedical Genetics and Cancer Genomics Centre, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands.


Histone deacetylase inhibitors comprise a variety of natural and synthetic compounds, which have in common that they inhibit enzymes that mediate the removal of acetyl groups from a range of proteins, including nucleosomal histones. Histone deacetylase inhibitors have anti-cancer activities in vitro and in vivo and are used in the clinic for the treatment of advanced cutaneous T cell lymphoma. The molecular pathways targeted by these compounds are discussed with an emphasis on the effects of these compounds on retinoic acid signaling.

[Indexed for MEDLINE]

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