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Semin Cell Dev Biol. 2008 Aug;19(4):311-8. doi: 10.1016/j.semcdb.2008.08.010. Epub 2008 Aug 26.

Inteferons pen the JAK-STAT pathway.

Author information

1
Department of Microbiology, Columbia University, New York, NY 10032, USA. cws4@columbia.edu

Abstract

Characterization of how interferons (IFNs) mediate their biological response led to identification of the JAK-STAT signaling cascade, where JAKs are receptor-associated kinases and STATs the transcription factors they activate. Today, 4 JAKs and 7 STATs are known to transduce pivotal signals for the over 50 members of the four-helix bundle family of cytokines. This review will provide an overview and historical perspective of the JAK-STAT paradigm.

PMID:
18765289
PMCID:
PMC2741134
DOI:
10.1016/j.semcdb.2008.08.010
[Indexed for MEDLINE]
Free PMC Article

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