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Zhonghua Yu Fang Yi Xue Za Zhi. 2008 Apr;42(4):235-8.

[Effects of marine collagen peptide on delaying the skin aging].

[Article in Chinese]

Author information

1
Department of Food and Nutritional Hygiene, School of Public Health, Beijing University, Beijing 100083, China.

Abstract

OBJECTIVE:

To investigate the protective effect of marine collagen peptides (MCPs) on the skin of aged mice induced by D-galactose.

METHODS:

Subchronic toxicity study was conducted while D-galactose induced subacute aging model was established. D-galactose dose of 0.125 g/kg body weight was intraperitoneally injected daily for 90 days. Marine collagen peptide 0.225, 0.450, 1.350 g/kg body weight were administered by oral gavage. Superoxide dismutase (SOD), catalase (CAT) activity and malondialdehyde (MDA) content in blood serum were measured, along with cutaneous histopathology examination.

RESULTS:

Epidermal thickness was significantly higher in MCPs treated group. Number and activity of fibroblast in MCPs treated dermis was increased prominently. The activity of SOD in 0.225, 0.450, 1.350 g/kgbw MCPs treated groups were 455.52 +/- 11.39, 460.15 +/- 18.09, 468.59 +/- 27.25 U/ml respectively, each of which was significantly higher than that in model control group; the activity of serum CAT in 0.225, 1.350 g/kgbw MCPs treated groups (21.33 +/- 4.82, 21.69 +/- 1.68 U/ml) were obviously increased compared with that in model control group (17.14 +/- 2.81 U/ml); MDA level in 0.450, 1.350 g/kgbw MCPs treated groups were 5.67 +/- 0.93, 5.76 +/- 1.02 nmol/ml respectively, each of which was significantly lower than that in model control group (7.63 +/- 1.37 nmol/ml).

CONCLUSIONS:

The results showed that MCPs might play a protective role on skin aging by improving the activity of antioxidant.

PMID:
18763632
[Indexed for MEDLINE]

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