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Nature. 1991 Aug 22;352(6337):689-95.

Cloning of a human gene encoding the general transcription initiation factor IIB.

Author information

1
Department of Biochemistry, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, Piscataway 08854-5635.

Abstract

Transcription factor IIB (TFIIB) has a central role in transcription of class II genes. The purification of the human TFIIB protein and isolation of a complementary DNA encoding TFIIB activity is reported here. The sequence of TFIIB, which seems to be encoded by a single gene, contains a repeated motif, in addition to a motif with similarity to the prokaryotic sigma-factors. The recombinant protein expressed in bacteria substituted for all the functions attributed to the human TFIIB protein.

PMID:
1876184
DOI:
10.1038/352689a0
[Indexed for MEDLINE]

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