Format

Send to

Choose Destination
See comment in PubMed Commons below
Exp Cell Res. 2009 Feb 15;315(4):602-10. doi: 10.1016/j.yexcr.2008.08.005. Epub 2008 Aug 19.

The role of the EGF family of ligands and receptors in renal development, physiology and pathophysiology.

Author information

1
Department of Medicine, C-3121 Medical Center North, Vanderbilt University, Nashville, Tennessee 37232-4794, USA.

Abstract

Mammalian kidney expresses all of the members of the ErbB family of receptors and their respective ligands. Studies support a role for ErbB family receptor activation in kidney development and differentiation. Under physiologic conditions, EGFR activation appears to play an important role in the regulation of renal hemodynamics and electrolyte handling by the kidney, while in different pathophysiologic states, EGFR activation may mediate either beneficial or detrimental effects to the kidney. This article provides an overview of the expression profile of the ErbB family of ligands and receptors in the mammalian kidney and summarizes known physiological and pathophysiological roles of EGFR activation in the organ.

PMID:
18761338
PMCID:
PMC2654782
DOI:
10.1016/j.yexcr.2008.08.005
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science Icon for PubMed Central
    Loading ...
    Support Center