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Eur J Cancer. 2008 Oct;44(15):2254-8. doi: 10.1016/j.ejca.2008.06.041. Epub 2008 Aug 27.

Immunochemical faecal occult blood tests are superior to guaiac-based tests for the detection of colorectal neoplasms.

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Registre des Cancers Digestifs, INSERM U866, Faculté de Médecine, Université de Bourgogne, CHU de Dijon, BP 87900, 21079 Dijon, France.


The aim of this study was to compare the performance of a guaiac-based faecal occult blood test (G-FOBT) with that of an immunochemical faecal occult blood test (I-FOBT). A total of 17,215 average risk individuals aged 50 to 74 enrolled in a population-based organised screening programme and performed a 3-day G-FOBT and a 2-day I-FOBT simultaneously. Among participants, 3.1% were found positive for the G-FOBT and 6.9% for the I-FOBT (p<10(-4)). Among the 1205 participants who tested positive and underwent a colonoscopy, the number of detected cancers and advanced adenomas was respectively 2.6 times higher and 3.5 times higher with the I-FOBT than with the G-FOBT. The positive predictive value of I-FOBT was similar to that of the G-FOBT for cancers (5.9% versus 5.2%) and was higher for advanced adenomas (27.2% versus 17.5%). The I-FOBT was superior to the G-FOBT for the detection of both cancers and advanced adenomas. However, the screen positive rate that staff and financial resources can accommodate has yet to be determined.

[Indexed for MEDLINE]

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