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Oncogene. 2008 Sep 1;27(38):5115-23. doi: 10.1038/onc.2008.225.

Notch tumor suppressor function.

Author information

1
Department of Biochemistry, Lausanne University, Epalinges, Switzerland. gian-paolo.dotto@unil.ch

Abstract

Cancer development results from deregulated control of stem cell populations and alterations in their surrounding environment. Notch signaling is an important form of direct cell-cell communication involved in cell fate determination, stem cell potential and lineage commitment. The biological function of this pathway is critically context dependent. Here we review the pro-differentiation role and tumor suppressing function of this pathway, as revealed by loss-of-function in keratinocytes and skin, downstream of p53 and in cross-connection with other determinants of stem cell potential and/or tumor formation, such as p63 and Rho/CDC42 effectors. The possibility that Notch signaling elicits a duality of signals, involved in growth/differentiation control and cell survival will be discussed, in the context of novel approaches for cancer therapy.

PMID:
18758480
PMCID:
PMC2747622
DOI:
10.1038/onc.2008.225
[Indexed for MEDLINE]
Free PMC Article

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