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Nat Genet. 2008 Oct;40(10):1153-5. doi: 10.1038/ng.214. Epub 2008 Aug 31.

Evidence for two independent prostate cancer risk-associated loci in the HNF1B gene at 17q12.

Author information

1
Center for Cancer Genomics, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157, USA.

Abstract

We carried out a fine-mapping study in the HNF1B gene at 17q12 in two study populations and identified a second locus associated with prostate cancer risk, approximately 26 kb centromeric to the first known locus (rs4430796); these loci are separated by a recombination hot spot. We confirmed the association with a SNP in the second locus (rs11649743) in five additional populations, with P = 1.7 x 10(-9) for an allelic test of the seven studies combined. The association at each SNP remained significant after adjustment for the other SNP.

PMID:
18758462
PMCID:
PMC3188432
DOI:
10.1038/ng.214
[Indexed for MEDLINE]
Free PMC Article

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