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Neuro Oncol. 2009 Feb;11(1):92-5. doi: 10.1215/15228517-2008-071. Epub 2008 Aug 29.

Colon perforation during antiangiogenic therapy for malignant glioma.

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1
Division of Neuro-Oncology, Department of Neurology, Brigham and Women's Hospital, Boston, MA, USA. anorden@partners.org

Abstract

Antiangiogenic drugs have emerged as effective treatment options for patients with recurrent malignant gliomas (MGs). Though this class of drugs is generally well tolerated, rare life-threatening complications, including thromboembolism, hemorrhage, and gastrointestinal (GI) perforation, are reported. We describe six cases of GI perforation among 244 glioma patients (2.5%) during treatment with antiangiogenic agents in combination with chemotherapy and corticosteroids. Two patients succumbed to this complication, and the others recovered. Because GI perforation is a life-threatening yet treatable complication, neurooncologists must have a low threshold to consider it in patients on antiangiogenic drug therapy who present with abdominal pain and other GI complaints.

PMID:
18757774
PMCID:
PMC2718964
DOI:
10.1215/15228517-2008-071
[Indexed for MEDLINE]
Free PMC Article
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