Format

Send to

Choose Destination
Ann Nucl Med. 2008 Aug;22(7):571-7. doi: 10.1007/s12149-008-0160-1. Epub 2008 Aug 29.

Diagnostic performance of PET/CT in differentiation of malignant and benign non-solid solitary pulmonary nodules.

Author information

1
Division of Thoracic Surgery, National Cancer Center Hospital, Tokyo, Japan.

Abstract

OBJECTIVE:

To evaluate whether [F-18] fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) can distinguish benign from malignant solitary pulmonary nodules (SPNs) with non-solid components.

METHODS:

[F-18] FDG-PET/CT scans were performed on 53 consecutive patients (30 men, 23 women; mean age 65 years) who had SPNs with non-solid components identified by CT screening for lung cancer. All patients underwent surgical resection, and all lesions were pathologically proved. Visual score, maximal, and mean standardized uptake value (SUV), and maximal and mean lesion-to-normal tissue count density ratio (LNR) were calculated in all lesions. In addition, clinical characteristics, laboratory test results, and CT findings were assessed.

RESULTS:

Benign SPNs with non-solid components had a higher uptake on [F-18] FDG-PET/CT. Visual score, maximal and mean SUV, and maximal and mean LNR were significantly higher in the benign when compared with the malignant SPNs (P < 0.001). When the cutoff of 1.5 was assigned for maximal SUV, the diagnostic performance of [F-18] FDG-PET/CT in predicting benign SPN revealed 100.0% sensitivity, 96.4% specificity, and 100.0% accuracy.

CONCLUSIONS:

[F-18] FDG-PET/CT is useful for the differential diagnosis of SPNs with non-solid components.

PMID:
18756359
DOI:
10.1007/s12149-008-0160-1
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Springer
Loading ...
Support Center