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Nat Rev Cancer. 2008 Oct;8(10):799-806. doi: 10.1038/nrc2500. Epub 2008 Aug 29.

Replication licensing and cancer--a fatal entanglement?

Author information

1
Wellcome Trust Centre for Gene Regulation & Expression, University of Dundee, DD1 5EH, UK. j.j.blow@dundee.ac.uk

Abstract

Correct regulation of the replication licensing system ensures that chromosomal DNA is precisely duplicated in each cell division cycle. Licensing proteins are inappropriately expressed at an early stage of tumorigenesis in a wide variety of cancers. Here we discuss evidence that misregulation of replication licensing is a consequence of oncogene-induced cell proliferation. This misregulation can cause either under- or over-replication of chromosomal DNA, and could explain the genetic instability commonly seen in cancer cells.

PMID:
18756287
PMCID:
PMC2577763
DOI:
10.1038/nrc2500
[Indexed for MEDLINE]
Free PMC Article

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