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J Med Chem. 2008 Sep 25;51(18):5502-5. doi: 10.1021/jm800839j.

Discovery of orally bioavailable cathepsin S inhibitors for the reversal of neuropathic pain.

Author information

1
Novartis Institutes for BioMedical Research, Ohkubo 8, Tsukuba, Ibaraki 300-2611, Japan. osamu.irie@novartis.com.

Abstract

Cathepsin S inhibitors are well-known to be an attractive target as immunological therapeutic agents. Recently, our gene expression analysis identified that cathepsin S inhibitors could also be effective for neuropathic pain. Herein, we describe the efficacy of selective cathepsin S inhibitors as antihyperalgesics in a model of neuropathic pain in rats after oral administration.

PMID:
18754655
DOI:
10.1021/jm800839j
[Indexed for MEDLINE]

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