Send to

Choose Destination
N Engl J Med. 2008 Aug 28;359(9):895-905. doi: 10.1056/NEJMoa0801187.

A randomized, controlled trial of magnesium sulfate for the prevention of cerebral palsy.

Collaborators (205)

Hauth J, Northen A, Nelson KG, Peralta-Carcelen M, Hill-Webb T, Tate S, Lee C, Bailey K, Chopko S, Rector R, Biasini FJ, Anderson K, Guzman A, Jensen M, Bodnar A, Adams L, Fullmer L, Thompson M, Williams L, Steffen M, Miller A, Leveno K, Sherman ML, Dax J, Faye-Randall L, Melton C, Heyne R, Hicks P, Broyles RS, Flores E, Orduno P, Cordova B, Dooley C, Boatman C, VanBuren G, Milluzzi C, Santori C, Collin M, Fundzak M, Nielsen B, Johnson F, Landon MB, Latimer C, Curry V, Meadows S, Cordero L, Timan C, Giannone P, Brenner S, Selegue R, Sciscione A, DiVito MM, Desai S, Esterly K, Duran C, Paul D, Herman A, DiVito P, Sherman M, O'Shea A, Talucci M, Gringlas M, Higley AM, Gaines E, Colley N, Higley EA, Sibai BM, Ramsey R, Mabie B, Kao L, Cassie M, Petersen M, Talati A, Whitaker T, Bada H, McKeever J, Werkman S, Rowland J, Pollard L, Norman GS, Steffy B, Dombrowski MP, Delaney-Black V, Johnson Y, Driscoll D, Goldston L, Boyes K, Meis P, Swain M, Klinepeter K, O'Shea M, Heller C, Steele L, Kiger M, Kreeger J, Waldrep E, Rhodes K, Allred D, Halfond R, Hounshell G, Hall N, Barr L, Moise KJ Jr, Brody S, Dorman K, Milowic K, Marshall D, Bernhardt J, Bostic L, Gilstrap LC 3rd, Day MC, Gildersleeve E, Ortiz F, Kerr M, Morris BH, Chavarria M, Bradt P, Legé-Humbert S, Dieterich S, Pemberton V, Bousleiman S, Paley C, Lee J, Paley L, Carmona V, Tillinghast J, Allard D, McCarten K, Vohr B, Noel L, Mejia C, Watson V, Leonard M, Leach T, Elder N, Girdler W, Steichen J, Gratton T, Lindheimer M, Jones P, Roizen N, Gray L, Wicks C, Rossi A, Plesha-Troyke S, Doyle F, Alfonso C, Scott M, Washington R, Fajardo-Hiriart S, Londono A, Rocha-Rodriguez G, Worth A, Griffin W, Allison M, Diaz A, Frade-Eguaras S, Mallett G, Simon P, deRegnier R, de Ungria M, Mestan K, Ramos-Brinson M, Bethel L, Weissbourd M, Shivers M, Goodrum LA, Saade GR, Munn M, Moss J, Brandon J, Olson GL, Harirah HM, Martin E, Dallas D, Santiago T, Stratton B, Shipley E, Smith K, Xenakis E, Conway D, Berkus M, Castro R, Odom M, Skiver D, Ramirez N, Miller E, McLerran C, Matula-Linkhart K, Cotroneo M, Milford C, Hofkosh D, Kamon T, Milford C, Weiner S, Jones-Binns B, Hoover M, Fischer M, McLaughlin S, Brunette K, Fricks E, Pagliaro S, McNellis D, Katz C, Howell K.

Author information

University of Alabama at Birmingham, Birmingham, USA.



Research suggests that fetal exposure to magnesium sulfate before preterm birth might reduce the risk of cerebral palsy.


In this multicenter, placebo-controlled, double-blind trial, we randomly assigned women at imminent risk for delivery between 24 and 31 weeks of gestation to receive magnesium sulfate, administered intravenously as a 6-g bolus followed by a constant infusion of 2 g per hour, or matching placebo. The primary outcome was the composite of stillbirth or infant death by 1 year of corrected age or moderate or severe cerebral palsy at or beyond 2 years of corrected age.


A total of 2241 women underwent randomization. The baseline characteristics were similar in the two groups. Follow-up was achieved for 95.6% of the children. The rate of the primary outcome was not significantly different in the magnesium sulfate group and the placebo group (11.3% and 11.7%, respectively; relative risk, 0.97; 95% confidence interval [CI], 0.77 to 1.23). However, in a prespecified secondary analysis, moderate or severe cerebral palsy occurred significantly less frequently in the magnesium sulfate group (1.9% vs. 3.5%; relative risk, 0.55; 95% CI, 0.32 to 0.95). The risk of death did not differ significantly between the groups (9.5% vs. 8.5%; relative risk, 1.12; 95% CI, 0.85 to 1.47). No woman had a life-threatening event.


Fetal exposure to magnesium sulfate before anticipated early preterm delivery did not reduce the combined risk of moderate or severe cerebral palsy or death, although the rate of cerebral palsy was reduced among survivors. ( number, NCT00014989.)

[Indexed for MEDLINE]
Free PMC Article

Publication types, MeSH terms, Substances, Secondary source ID, Grant support

Publication types

MeSH terms


Secondary source ID

Grant support

Supplemental Content

Full text links

Icon for Atypon Icon for PubMed Central
Loading ...
Support Center