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Bioorg Med Chem Lett. 2008 Sep 15;18(18):5027-31. doi: 10.1016/j.bmcl.2008.08.014. Epub 2008 Aug 9.

1-Benzylbenzimidazoles: the discovery of a novel series of bradykinin B(1) receptor antagonists.

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1
Neurogen Corporation, 35 NE Industrial Road, Branford, CT 06405, USA.

Abstract

The design, synthesis, and structure-activity studies of a novel series of BK B(1) receptor antagonists based on a 1-benzylbenzimidazole chemotype are described. A number of compounds, for example, 38g, with excellent affinity for the cynomolgus macaque and rat bradykinin B(1) receptor were discovered.

PMID:
18752949
DOI:
10.1016/j.bmcl.2008.08.014
[Indexed for MEDLINE]

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