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Genetica. 1991;84(1):51-5.

Fluctuation analysis: the effect of plating efficiency.

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Department of Mathematics, Brown University, Providence, RI 02912.


This paper supplements an earlier paper which explained how to calculate the probability distribution of the number of mutants that would be observed in a fluctuation test experiment. The formulas in that work give the distributions to be expected under a wide variety of experimental conditions, but the method it uses when only a fraction of the mutants will produce visible colonies are clumsy and inefficient. Here I describe efficient procedures for dealing with that case, provided that the mutation rate per cell division remains constant during the experiment.

[Indexed for MEDLINE]

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