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Annu Rev Microbiol. 2008;62:211-33. doi: 10.1146/annurev.micro.61.080706.093422.

RNA polymerase elongation factors.

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1
Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York 14853, USA. jwr7@cornell.edu

Abstract

The elongation phase of transcription by RNA polymerase is highly regulated and modulated. Both general and operon-specific elongation factors determine the local rate and extent of transcription to coordinate the appearance of transcript with its use as a messenger or functional ribonucleoprotein or regulatory element, as well as to provide operon-specific gene regulation.

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