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J Am Chem Soc. 2008 Sep 24;130(38):12608-9. doi: 10.1021/ja804930d. Epub 2008 Aug 26.

Electron tomography shows molecular anchoring within a layer-by-layer film.

Author information

  • 1Soft Matter Cryo-TEM Research Unit, Eindhoven University of Technology, P.O. Box 513, 5600 MB Eindhoven, The Netherlands.

Abstract

The layer-by-layer self-assembly of thin films consisting of alternating layers of DNA and bis-urea nanoribbons prevents diffusion of the components within the film and allows the anchoring of biotinylated molecules through molecular recognition in a predetermined layer of the film. Electron tomography demonstrates with nanometer precision the location of gold-labeled streptavidin bound to the incorporated biotinylated molecules.

PMID:
18729366
DOI:
10.1021/ja804930d
[PubMed - indexed for MEDLINE]
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