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Cell Cycle. 2008 Sep 1;7(17):2621-5. Epub 2008 Sep 26.

PI3-K and GSK-3: Akt-ing together with microtubules.

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1
Department of Zoology, University of Oxford, Oxford, United Kingdom.

Abstract

Phosphoinositide-3-Kinase (PI3-K) and the downstream kinases Akt and Glycogen Synthase Kinase-3 (GSK-3) have recently been implicated in regulating both microtubule (MT) dynamics and organization. Here we review the role of this signalling pathway in controlling MTs, and explore ways in which the kinases and their substrates may co-operate to spatially regulate MTs in different contexts.

PMID:
18728390
DOI:
10.4161/cc.7.17.6514
[Indexed for MEDLINE]
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