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Clin Microbiol Infect. 2008 Aug;14(8):797-801. doi: 10.1111/j.1469-0691.2008.02025.x.

Antibiotic susceptibility and molecular epidemiology of nasopharyngeal pneumococci from Spanish children.

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Fundación Reina Mercedes, Hospital Universitario Virgen del Rocío, Sevilla.


Nasopharyngeal pneumococci were collected from 635 Spanish children aged 6 months to 6 years attending four primary healthcare centres (n = 276) or two hospital emergency rooms (n = 359); 36% of the children had received >/=1 dose of pneumococcal conjugate vaccine (PCV7). Overall, the carriage rate of Streptococcus pneumoniae was 31%, with no significant differences in carriage rates according to setting. Colonization with vaccine serotypes was significantly associated with the absence of PCV7 immunization (29.4% vs. 5.9%, p <0.001). Forty-seven per cent of all isolates were penicillin- and/or erythromycin-non-susceptible; 13 international antibiotic-resistant clones were represented among non-susceptible pneumococci and were similarly distributed among vaccine and non-vaccine serotypes.

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