Format

Send to

Choose Destination
Cell Mol Life Sci. 2009 Jan;66(1):82-93. doi: 10.1007/s00018-008-8378-6.

The bacterial LexA transcriptional repressor.

Author information

1
School of Biosciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, United Kingdom. M.Butala@bham.ac.uk

Abstract

Bacteria respond to DNA damage by mounting a coordinated cellular response, governed by the RecA and LexA proteins. In Escherichia coli, RecA stimulates cleavage of the LexA repressor, inducing more than 40 genes that comprise the SOS global regulatory network. The SOS response is widespread among bacteria and exhibits considerable variation in its composition and regulation. In some well-characterised pathogens, induction of the SOS response modulates the evolution and dissemination of drug resistance, as well as synthesis, secretion and dissemination of the virulence. In this review, we discuss the structure of LexA protein, particularly with respect to distinct conformations that enable repression of SOS genes via specific DNA binding or repressor cleavage during the response to DNA damage. These may provide new starting points in the battle against the emergence of bacterial pathogens and the spread of drug resistance among them.

PMID:
18726173
DOI:
10.1007/s00018-008-8378-6
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Springer
Loading ...
Support Center