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Clin Auton Res. 2009 Feb;19(1):13-9. doi: 10.1007/s10286-008-0488-6. Epub 2008 Aug 22.

Antibody testing as a diagnostic tool in autonomic disorders.

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1
Department of Neurology, University of Texas, Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX 75390-9036, USA. steven.vernino@utsouthwestern.edu

Abstract

Some forms of peripheral autonomic dysfunction (especially enteric neuropathy and subacute panautonomic failure) occur as autoimmune phenomena either in isolation or in the context of cancer. Autoimmune autonomic ganglionopathy is an example of a severe, but potentially treatable, antibody-mediated form of autonomic failure. Diagnostic evaluation of autonomic disorders can be supplemented by testing for paraneoplastic antibodies and antibodies against membrane receptors. The diagnostic antibodies most commonly associated with dysautonomia are paraneoplastic antibodies (anti-Hu and CRMP-5) and ganglionic acetylcholine receptor antibodies.

PMID:
18726055
DOI:
10.1007/s10286-008-0488-6
[Indexed for MEDLINE]
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