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J Crit Care. 2008 Sep;23(3):339-48. doi: 10.1016/j.jcrc.2007.11.004. Epub 2008 May 2.

Modeling in-hospital patient survival during the first 28 days after intensive care unit admission: a prognostic model for clinical trials in general critically ill patients.

Author information

1
Unidade de Cuidados Intensivos Polivalente, Hospital de St. António dos Capuchos, Centro Hospitalar de Lisboa Central, E. P. E., Lisboa, Portugal.

Abstract

OBJECTIVE:

The objective of the study was to develop a model for estimating patient 28-day in-hospital mortality using 2 different statistical approaches.

DESIGN:

The study was designed to develop an outcome prediction model for 28-day in-hospital mortality using (a) logistic regression with random effects and (b) a multilevel Cox proportional hazards model.

SETTING:

The study involved 305 intensive care units (ICUs) from the basic Simplified Acute Physiology Score (SAPS) 3 cohort.

PATIENTS AND PARTICIPANTS:

Patients (n = 17138) were from the SAPS 3 database with follow-up data pertaining to the first 28 days in hospital after ICU admission.

INTERVENTIONS:

None.

MEASUREMENTS AND RESULTS:

The database was divided randomly into 5 roughly equal-sized parts (at the ICU level). It was thus possible to run the model-building procedure 5 times, each time taking four fifths of the sample as a development set and the remaining fifth as the validation set. At 28 days after ICU admission, 19.98% of the patients were still in the hospital. Because of the different sampling space and outcome variables, both models presented a better fit in this sample than did the SAPS 3 admission score calibrated to vital status at hospital discharge, both on the general population and in major subgroups.

CONCLUSIONS:

Both statistical methods can be used to model the 28-day in-hospital mortality better than the SAPS 3 admission model. However, because the logistic regression approach is specifically designed to forecast 28-day mortality, and given the high uncertainty associated with the assumption of the proportionality of risks in the Cox model, the logistic regression approach proved to be superior.

PMID:
18725038
DOI:
10.1016/j.jcrc.2007.11.004
[Indexed for MEDLINE]

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