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Cell. 2008 Aug 22;134(4):569-71. doi: 10.1016/j.cell.2008.08.010.

Linking retroelements to autoimmunity.

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1
Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390-9148, USA.

Abstract

In this issue, Stetson et al. (2008) report a mechanism by which host cells avert an autoimmune response to self-nucleic acids. They show that the nuclease Trex1 prevents the accumulation of DNA derived from endogenous retroelements that, if left unchecked, trigger elevated production of type I interferons leading to autoimmunity.

PMID:
18724930
DOI:
10.1016/j.cell.2008.08.010
[Indexed for MEDLINE]
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