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Indian J Pathol Microbiol. 2008 Jul-Sep;51(3):402-4.

Cytomegalovirus infection with lissencephaly.

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1
Department of Pathology, Sri Ramachandra University, Chennai, Tamil Nadu, India.

Abstract

Lissencephaly is a malformation of the brain in which the brain surface is smooth, rather than convoluted. Among the various causes of lissencephaly, infection by a virus during pregnancy plays an important role. Cytomegalovirus (CMV) is an important pathogen causing this anomaly. We present this case of a young female with 24-week-gestation diagnosed on ultrasound as carrying an anomalous fetus with lissencephalic features. At autopsy, there were multiple intra-nuclear CMV inclusions in the brain and the kidneys. This case is presented for its rarity and for the documentation of the tissue localization of CMV inclusions at autopsy.

PMID:
18723971
[Indexed for MEDLINE]
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