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Blood. 2008 Nov 15;112(10):4048-50. doi: 10.1182/blood-2008-07-166587. Epub 2008 Aug 22.

Plasmin therapy enhances mobilization of HPCs after G-CSF.

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1
Vesalius Research Center, Leuven, Belgium.

Erratum in

  • Blood. 2009 May 21;113(21):5368.

Abstract

The role of proteinases in the mobilization of hematopoietic progenitor cells (HPCs) after granulocyte colony-stimulating factor (G-CSF) remains unclear. Here we report that genetic loss of the plasminogen activator inhibitor Pai-1 or of the plasmin inhibitor alpha2-antiplasmin increases HPC mobilization in response to G-CSF. Moreover, thrombolytic agents, such as tenecteplase and microplasmin, enhance HPC mobilization in mice and humans. Taken together, these findings identify a novel role for plasmin in augmenting HPC mobilization in response to G-CSF.

PMID:
18723692
PMCID:
PMC2581978
DOI:
10.1182/blood-2008-07-166587
[Indexed for MEDLINE]
Free PMC Article
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