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Int J Biochem Cell Biol. 2009 Apr;41(4):740-3. doi: 10.1016/j.biocel.2008.05.027. Epub 2008 Aug 3.

RBM4: a multifunctional RNA-binding protein.

Author information

1
Basic & Clinical Genomics Laboratory, School of Medical Sciences and Bosch Institute, Building F13, The University of Sydney, Sydney, NSW 2006, Australia.

Abstract

RBM4, also known as Lark, was described initially as having a role in circadian rhythm control in Drosophila. In the last 5 years data have emerged from studies of mammalian cells. It is now clear that RBM4 is an RNA-binding protein involved in diverse cellular processes that include alternative splicing of pre-mRNA, translation, and RNA silencing. Its structure, similar to other RNA-binding proteins, contains two RNA recognition motifs and a CCHC-type zinc finger. Here we review current information about the function of RBM4 and its localization within the cell. We then speculate about its possible relationship to disease.

PMID:
18723113
DOI:
10.1016/j.biocel.2008.05.027
[Indexed for MEDLINE]

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