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Trends Biotechnol. 2008 Nov;26(11):602-11. doi: 10.1016/j.tibtech.2008.07.003. Epub 2008 Aug 21.

Single-molecule DNA sequencing technologies for future genomics research.

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Department of Genetics and Plant Breeding, Chaudhary Charan Singh University, Meerut 250004, India.


During the current genomics revolution, the genomes of a large number of living organisms have been fully sequenced. However, with the advent of new sequencing technologies, genomics research is now at the threshold of a second revolution. Several second-generation sequencing platforms became available in 2007, but a further revolution in DNA resequencing technologies is being witnessed in 2008, with the launch of the first single-molecule DNA sequencer (Helicos Biosciences), which has already been used to resequence the genome of the M13 virus. This review discusses several single-molecule sequencing technologies that are expected to become available during the next few years and explains how they might impact on genomics research.

[Indexed for MEDLINE]

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