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J Trauma Stress. 2008 Aug;21(4):417-20. doi: 10.1002/jts.20351.

Nonnightmare distressed awakenings in veterans with posttraumatic stress disorder: response to prazosin.

Author information

1
VA Northwest Network, Mental Illness Research, Education and Clinical Center, Seattle, WA 98108, USA.

Abstract

Twenty-two veterans with posttraumatic stress disorder (PTSD) were assessed for trauma-related nightmares and nonnightmare distressed awakenings (NNDA) before and after treatment with the alpha-1 adrenoreceptor antagonist prazosin at an average bedtime dose of 9.6 mg/day. Ratings combining frequency and intensity dimensions of trauma-related nightmares decreased from 3.6 to 2.2, NNDA from 5.2 to 2.1, and sleep difficulty from 7.2 to 4.1 per week. These results suggest that increased brain adrenergic activity may contribute to the pathophysiology of both trauma-related nightmares and NNDA in PTSD.

PMID:
18720392
PMCID:
PMC4542062
DOI:
10.1002/jts.20351
[Indexed for MEDLINE]
Free PMC Article
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