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Nat Rev Mol Cell Biol. 2008 Sep;9(9):673-8. doi: 10.1038/nrm2479.

Endogenous small interfering RNAs in animals.

Author information

1
Department of Developmental Biology, Sloan-Kettering Institute, 521 Rockefeller Research Laboratories, New York, New York 10065, USA.

Abstract

Until recently, only nematodes among animals had a well-defined endogenous small interfering RNA (endo-siRNA) pathway. This has changed dramatically with the recent discovery of diverse intramolecular and intermolecular substrates that generate endo-siRNAs in Drosophila melanogaster and mice. These findings suggest broad and possibly conserved roles for endogenous RNA interference in regulating host-gene expression and transposable element transcripts. They also raise many questions regarding the biogenesis and function of small regulatory RNAs in animals.

PMID:
18719707
PMCID:
PMC2729316
DOI:
10.1038/nrm2479
[Indexed for MEDLINE]
Free PMC Article

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