Format

Send to

Choose Destination
See comment in PubMed Commons below
Phys Ther. 2008 Oct;88(10):1177-85. doi: 10.2522/ptj.20080043. Epub 2008 Aug 21.

In vitro optimization of dexamethasone phosphate delivery by iontophoresis.

Author information

  • 1Department of Pharmacy and Pharmacology, University of Bath, Claverton Down, Bath, United Kingdom.

Abstract

BACKGROUND AND PURPOSE:

This study was designed to evaluate the effects of competing ions and electroosmosis on the transdermal iontophoresis of dexamethasone phosphate (Dex-Phos) and to identify the optimal conditions for its delivery.

METHODS:

The experiments were performed using pig skin, in side-by-side diffusion cells (0.78 cm(2)), passing a constant current of 0.3 mA via Ag-AgCl electrodes. Dex-Phos transport was quantified for donor solutions (anodal and cathodal) containing different drug concentrations, with and without background electrolyte. Electrotransport of co-ion, citrate, and counterions Na(+) and K(+) also was quantified. The contribution of electroosmosis was evaluated by measuring the transport of the neutral marker (mannitol).

RESULTS:

Electromigration was the dominant mechanism of drug iontophoresis, and reduction in electroosmotic flow directed against the cathodic delivery of Dex-Phos did not improve drug delivery. The Dex-Phos flux from the cathode was found to be optimal (transport number of approximately 0.012) when background electrolyte was excluded from the formulation. In this case, transport of the drug is limited principally by the competition with counterions (mainly Na(+) with a transport number of approximately 0.8) and the mobility of the drug in the membrane.

DISCUSSION AND CONCLUSION:

Dex-Phos must be delivered from the cathode and formulated rationally, excluding mobile co-anions, to achieve optimal iontophoretic delivery.

Comment in

PMID:
18719003
PMCID:
PMC2557054
DOI:
10.2522/ptj.20080043
[PubMed - indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire Icon for PubMed Central
    Loading ...
    Support Center