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Urology. 2009 Apr;73(4):928.e17-9. doi: 10.1016/j.urology.2008.05.023. Epub 2008 Aug 21.

Paraneoplastic leukemoid reaction as marker for transitional cell carcinoma recurrence.

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Department of Medicine, University of California, San Francisco, California, USA.


A case of a 78-year-old man with transitional cell carcinoma and a paraneoplastic leukemoid reaction. The leukocytosis was present at the diagnosis of carcinoma. It dissipated with complete tumor resection, was absent when a surveillance computed tomography scan showed no evidence of recurrence at 6 months, and had returned with tumor recurrence at 8 months. This case demonstrates that a paraneoplastic leukemoid reaction can be used as a tumor marker in cases of transitional cell carcinoma when a leukemoid reaction is found at presentation.

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