Format

Send to

Choose Destination
See comment in PubMed Commons below
Contemp Clin Trials. 2009 Jan;30(1):40-6. doi: 10.1016/j.cct.2008.07.007. Epub 2008 Jul 31.

Why is recruitment to trials difficult? An investigation into recruitment difficulties in an RCT of supported employment in patients with severe mental illness.

Author information

1
Health Service and Population Research Department, PO29 Institute of Psychiatry, King's College London, De Crespigny Park, London, UK. l.howard@iop.kcl.ac.uk

Abstract

BACKGROUND:

Under-recruitment to randomised controlled trials (RCTs) is often problematic and there may be particular difficulties in recruiting patients with severe mental illness.

AIM:

To evaluate reasons for under-recruitment in an RCT of patients with severe mental illness

METHODS:

Qualitative study during the recruitment phase of an RCT of supported employment. Trial staff and recruiting clinicians were interviewed. Data were analyzed thematically using constant comparative techniques.

RESULTS:

Recruitment rates were low. Five main reasons for recruitment difficulties were found. These included: (i) misconceptions about trials, (ii) lack of equipoise, (iii) misunderstanding of the trial arms, (iv) variable interpretations of eligibility criteria, (v) paternalism.

CONCLUSION:

Reasons for recruitment difficulties in trials involving patients with severe mental illness include issues that occur in trials in general, but others are more specific to these patients. Clinician and patient involvement in the study design may improve recruitment in future similar trials.

PMID:
18718555
PMCID:
PMC2626649
DOI:
10.1016/j.cct.2008.07.007
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science Icon for PubMed Central
    Loading ...
    Support Center