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J Clin Immunol. 2008 Nov;28(6):677-84. doi: 10.1007/s10875-008-9242-z. Epub 2008 Aug 21.

T regulatory cells in autoimmune diabetes: past challenges, future prospects.

Author information

1
UCSF Diabetes Center, San Francisco, CA 94143, USA. jbluest@diabetes.ucsf.edu

Abstract

INTRODUCTION:

Accumulating evidence suggests that defective regulation is an essential underlying cause of autoimmunity. The development of type 1 diabetes in the NOD mouse strain it is a complex process that depends on a fine balance between pathogenic and regulatory pathways.

DISCUSSION:

We have utilized a series of transgenic and knockout mice to determine the relative importance of regulatory T cells and negative regulatory receptors on the development and progression of type 1 diabetes.

CONCLUSION:

This review will focus on the origins and function of Treg in peripheral self-tolerance. We will summarize the role of Treg in preventing autoimmune diseases, with a particular focus on Type 1 Diabetes (T1D), and discuss the prospects for Treg-based therapies for autoimmune diseases.

PMID:
18716861
DOI:
10.1007/s10875-008-9242-z
[Indexed for MEDLINE]

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