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Synapse. 1991 May;8(1):38-40.

GABA depolarizes neurons in the rat striatum: an in vivo study.

Author information

1
II Università di Roma, Dipartimento di Sanità Pubblica e Biologia Cellulare, Italy.

Abstract

GABA, applied by iontophoresis to striatal neurons of the rat in an in vivo preparation, depolarized the membrane potential and decreased the input resistance in a dose-dependent manner. The null potential of the GABA depolarization was about -50 mV. In addition, a fading of the GABA-induced response was observed for prolonged and relatively high amino acid application. We conclude that GABA has a depolarizing effect on striatal cells. This is in line with recent in vitro works describing a depolarizing effect of GABA in the rat neostriatum.

PMID:
1871679
DOI:
10.1002/syn.890080106
[Indexed for MEDLINE]

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