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Scand J Urol Nephrol. 1991;25(2):121-3.

Vasopressin and cortisol levels in response to glycine infusion.

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  • 1Department of Anaesthesiology, Huddinge University Hospital, Sweden.


The plasma vasopressin and serum cortisol concentrations were recorded in 7 healthy volunteers receiving an intravenous infusion of 1 l of isosmotic (2.2%) glycine solution during 20 min. The infusion elicited a significant increase in the plasma vasopressin level by a mean of 60% (SEM 13) above baseline level. The serum cortisol level increased only in the patient who developed signs of glycine toxicity. These results suggest that a glycine solution has water-retaining properties by stimulating the vasopressin secretion but usually not by increasing cortisol secretion.

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