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Biol Chem. 2008 Oct;389(10):1253-60. doi: 10.1515/BC.2008.143.

HIV-1 at the immunological and T-lymphocytic virological synapse.

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1
Department of Virology, University of Heidelberg, INF 324, D-69120 Heidelberg, Germany.

Abstract

Cell-cell transmission of human immunodeficiency virus type 1 (HIV-1) is considered the most effective mode of viral spread in T-lymphocyte cultures. Evidence has accumulated that HIV-1 assembles polarized synaptic-like structures, referred to as virological synapses, as specialized sites of viral transfer. Interestingly, it was recently also discovered that HIV-1 impairs the formation of the structurally similar immunological synapse, thereby modulating exogenous T-lymphocyte stimulation to yield an optimal activation state for productive HIV-1 infection. The careful dissection of these opposing effects will contribute to our understanding of retroviral spread and cellular signal transduction machineries.

PMID:
18713012
DOI:
10.1515/BC.2008.143
[Indexed for MEDLINE]
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