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Radiology. 2008 Sep;248(3):1028-35. doi: 10.1148/radiol.2483071927.

Simultaneous MR/PET imaging of the human brain: feasibility study.

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Department of Diagnostic Radiology, University Hospital Tübingen, Hoppe-Seyler-Strasse 3, D-72076 Tübingen, Germany.


The purpose of this study was to apply a magnetic resonance (MR) imaging-compatible positron emission tomographic (PET) detector technology for simultaneous MR/PET imaging of the human brain and skull base. The PET detector ring consists of lutetium oxyorthosilicate (LSO) scintillation crystals in combination with avalanche photodiodes (APDs) mounted in a clinical 3-T MR imager with use of the birdcage transmit/receive head coil. Following phantom studies, two patients were simultaneously examined by using fluorine 18 fluorodeoxyglucose (FDG) PET and MR imaging and spectroscopy. MR/PET data enabled accurate coregistration of morphologic and multifunctional information. Simultaneous MR/PET imaging is feasible in humans, opening up new possibilities for the emerging field of molecular imaging.

[Indexed for MEDLINE]

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