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Kidney Int. 2008 Sep;74(5):555-7. doi: 10.1038/ki.2008.325.

Macroautophagy: a mechanism for mediating cell death or for promoting cell survival?

Author information

1
Stony Brook University Hospital, Department of Medicine, Stony Brook, New York, USA. wlieberthal@notes.cc.sunysb.edu

Abstract

Macroautophagy is a ubiquitous mechanism for the bulk removal of macromolecules and cell organelles from the cell. Periyasamy-Thandavan and colleagues report that cisplatin activates autophagy in renal tubular cells and that autophagy plays a role in decreasing apoptosis of tubular cells induced by cisplatin. This finding provides novel evidence that autophagy may play a role in ameliorating the effects of acute injury on the kidney.

PMID:
18709025
DOI:
10.1038/ki.2008.325
[Indexed for MEDLINE]
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