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J Bacteriol. 2008 Nov;190(21):7298-301. doi: 10.1128/JB.00551-08. Epub 2008 Aug 15.

Involvement of an essential gene, mviN, in murein synthesis in Escherichia coli.

Author information

1
Department of Biological Sciences, Graduate School of Science, Tokyo Metropolitan University, Minamiohsawa, Hachioji, Tokyo 192-0397, Japan.

Abstract

We isolated a temperature-sensitive mutant with a mutation in mviN, an essential gene in Escherichia coli. At the nonpermissive temperature, mviN mutant cells swelled and burst. An intermediate in murein synthesis, polyprenyl diphosphate-N-acetylmuramic acid-(pentapeptide)-N-acetyl-glucosamine, accumulated in mutant cells. These results indicated that MviN is involved in murein synthesis.

PMID:
18708495
PMCID:
PMC2580715
DOI:
10.1128/JB.00551-08
[Indexed for MEDLINE]
Free PMC Article

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