Format

Send to

Choose Destination
See comment in PubMed Commons below
Sex Transm Infect. 2008 Dec;84(7):516-7. doi: 10.1136/sti.2008.032367. Epub 2008 Aug 15.

Apolipoprotein E-epsilon 4 and recurrent genital herpes in individuals co-infected with herpes simplex virus type 2 and HIV.

Author information

1
Department of Genito-Urinary Medicine, Hawthorn House, Heartlands Hospital, Bordsley Green East, Birmingham B9 5SS, UK. ashini@doctors.net.uk

Abstract

Apolipoprotein E (APOE) alleles have been associated with the severity of, or susceptibility to, infection by various microbes. We investigated the potential association between the APOE-epsilon 4 allele and the rate of recurrence of genital herpes in patients who were HIV positive and herpes simplex virus type 2 (HSV-2) seropositive. The APOE-epsilon 4 allele was significantly associated with recurrent genital ulceration independent of ethnicity, antiretroviral therapy and CD4 count (OR 8.3; 95% CI 2.4 to 28.5). To our knowledge, this is the first published study to demonstrate this association and suggests that APOE-epsilon 4 may represent a future prognostic marker for symptomatic recurrence of genital herpes in individuals with HIV.

PMID:
18708484
DOI:
10.1136/sti.2008.032367
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire
    Loading ...
    Support Center