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Mol Cancer Res. 2008 Aug;6(8):1289-92. doi: 10.1158/1541-7786.MCR-08-0036.

c-Jun Is critical for the progression of osteosarcoma: proof in an orthotopic spontaneously metastasizing model.

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1
Department of Orthopaedics, St. Vincent's Hospital, Fitzroy, Melbourne, Victoria 3065, Australia. cris.dass@yahoo.com

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  • Mol Cancer Res. 2009 Sep;7(9):1594.

Abstract

The oncogene c-Jun has been found to be up-regulated in a variety of cancers including osteosarcoma. DNA enzymes (DNAzymes) are oligonucleotides capable of specific catalysis of target mRNA. A c-Jun DNAzyme inhibited the growth and metastasis of osteosarcoma in an orthotopic spontaneously metastasizing model of the disease. c-Jun down-regulation-mediated apoptosis in osteosarcoma cells involved caspase-1, caspase-2, and caspase-8, but not the Fas/FasL pathway. Clinically, knockdown of c-Jun with DNAzymes may proffer an improved treatment outcome for these tumors originating in bone.

PMID:
18708361
DOI:
10.1158/1541-7786.MCR-08-0036
[Indexed for MEDLINE]
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