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Exp Cell Res. 2009 Feb 15;315(4):619-26. doi: 10.1016/j.yexcr.2008.07.025. Epub 2008 Aug 3.

HB-EGF: a unique mediator of embryo-uterine interactions during implantation.

Author information

1
Department of Biomedical Science & Technology, Research Center for Drugs, IBST, Konkuk University, 1 Hwayang-dong, Kwangjin-gu, Seoul 143-701 Korea. hlim@konkuk.ac.kr

Abstract

An implantation-competent blastocyst, several hours prior to its attachment on the uterine wall, transmits signals to surrounding uterine cells and vice-versa to initiate a two-way interaction. The language of this precocious dialogue is versatile, taking advantage of secreted molecules for long-range interactions and membrane-bound molecules for more immediate interactions. Heparin-binding epidermal growth factor-like growth factor (HB-EGF) was identified as an early messenger of implantation which uses both modes of communication. In this review, we discuss the footprint of HB-EGF as to how it was initially identified as a mediator of implantation and how it initiates embryo-uterine interactions during this process.

PMID:
18708050
PMCID:
PMC2672567
DOI:
10.1016/j.yexcr.2008.07.025
[Indexed for MEDLINE]
Free PMC Article

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