Format

Send to

Choose Destination
Cytokine. 2008 Sep;43(3):359-67. doi: 10.1016/j.cyto.2008.07.012. Epub 2008 Aug 15.

Roles of ubiquitination in pattern-recognition receptors and type I interferon receptor signaling.

Author information

1
Faculté de Pharmacie, Université de Montréal, CP 6128, succursale Centre-Ville, Montréal, Québec, Canada.

Abstract

Post-translational protein modifications are involved in all functions of living cells. This includes the ability of cells to recognize pathogens and regulate genes involved in their clearance, a concept known as innate immunity. While phosphorylation mechanisms play essential roles in regulating different aspects of the innate immune response, ubiquitination is now recognized as another post-translational modification that works in parallel with phosphorylation to orchestrate the final proper innate immune response against invading pathogens. More precisely, this review will discuss the most recent advances that address the role of ubiquitination in pattern-recognition receptors and type I interferon receptor signaling.

PMID:
18707898
DOI:
10.1016/j.cyto.2008.07.012
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center