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Psychiatry Res. 2008 Oct 30;164(1):77-80. doi: 10.1016/j.pscychresns.2007.12.006. Epub 2008 Aug 15.

Cerebral metabolic patterns in untreated postmenopausal women with major depressive disorder.

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Stanford Center for Neuroscience in Women's Health, Department of Psychiatry and Behavioral Sciences, 401 Quarry Road, Stanford University School of Medicine, Stanford, CA, United States.


Cerebral metabolic rates were assessed using [(18)F]-fluorodeoxyglucose positron emission tomography in six naturally postmenopausal women with untreated unipolar depression and 11 matched controls. All subjects were hormone therapy-naive and medication-free. Findings include hypermetabolism in the middle frontal gyrus and Broca regions, and hypometabolism in the pons among depressed compared with non-depressed women.

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