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Psychiatry Res. 2008 Oct 30;164(1):77-80. doi: 10.1016/j.pscychresns.2007.12.006. Epub 2008 Aug 15.

Cerebral metabolic patterns in untreated postmenopausal women with major depressive disorder.

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1
Stanford Center for Neuroscience in Women's Health, Department of Psychiatry and Behavioral Sciences, 401 Quarry Road, Stanford University School of Medicine, Stanford, CA, United States. nrasgon@stanford.edu

Abstract

Cerebral metabolic rates were assessed using [(18)F]-fluorodeoxyglucose positron emission tomography in six naturally postmenopausal women with untreated unipolar depression and 11 matched controls. All subjects were hormone therapy-naive and medication-free. Findings include hypermetabolism in the middle frontal gyrus and Broca regions, and hypometabolism in the pons among depressed compared with non-depressed women.

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