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Virus Res. 2008 Nov;137(2):206-12. doi: 10.1016/j.virusres.2008.07.015. Epub 2008 Sep 6.

The circulation of subgenogroups B5 and C5 of enterovirus 71 in Taiwan from 2006 to 2007.

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Research and Diagnostic Center, Centers for Disease Control, Department of Health, Taipei, Taiwan.


Enteroviruses (EVs) are among the most common pathogens in humans. EV71 infections have caused devastating enterovirus-associated outcomes in children globally. In this study, eleven EV71 isolates in Taiwan during 2006-2007 were selected for N-terminal VP1 gene analysis. A fragment of 403 bp on VP1 gene was sequenced and a phylogenetic analysis was performed. In addition, the full-length genome sequencing was carried out on two selected isolates. The results showed that subgenogroups of B5 and C5 had circulated and become predominant in Taiwan over the specified 2 years. Moreover, glutamic acid and threonine are found conservative at positions 43 and 58 on VP1 for genogroup B; however they are replaced by lysine and alanine, respectively, for genogroup C. To our knowledge, this is the first report describing the circulation of these two EV71 subgenogroups in Taiwan.

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