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Genome Biol. 2008;9(8):R128. doi: 10.1186/gb-2008-9-8-r128. Epub 2008 Aug 15.

MotifCluster: an interactive online tool for clustering and visualizing sequences using shared motifs.

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1
Department of Computer Science, University of Colorado, Boulder, CO 80309, USA.

Abstract

MotifCluster finds related motifs in a set of sequences, and clusters the sequences into families using the motifs they contain. MotifCluster, at http://bmf.colorado.edu/motifcluster, lets users test whether proteins are related, cluster sequences by shared conserved motifs, and visualize motifs mapped onto trees, sequences and three-dimensional structures. We demonstrate MotifCluster's accuracy using gold-standard protein superfamilies; using recommended settings, families were assigned to the correct superfamilies with 0.17% false positive and no false negative assignments.

PMID:
18706079
PMCID:
PMC2575518
DOI:
10.1186/gb-2008-9-8-r128
[Indexed for MEDLINE]
Free PMC Article
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