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Arch Pharm Res. 2008 Jul;31(7):886-90. doi: 10.1007/s12272-001-1242-1. Epub 2008 Aug 14.

Anti-platelet effects of flavonoids and flavonoid-glycosides from Sophora japonica.

Author information

1
Natural Products Research Institute, College of Pharmacy, Seoul National University, Seoul, Korea.

Abstract

A methanol extract of Sophora japonica was subjected to anti-platelet activity guided fractionation affording the isolation of four flavonoids and six flavonoid-glycosides: biochanin A (1), irisolidone (2), genistein (3), sissotrin (4), sophorabioside (5), genistin (6), tectoridin (7), apigenin (8), quercitrin (9), and rutin (10). The structure of each compound was determined by a variety of spectroscopic methods. Among the compounds, 1, 3, and 7 showed approximately 2.5-6.5 fold greater inhibitory effects on arachidonic acid (AA) and U46619 induced platelet aggregation (IC50: 19.9 and 99.8 microM; 20.3 and 53.8 microM; 25.9 and 123.4 microM, respectively) than acetylsalicylic acid (ASA, IC50: 63.0 and 350.0 microM). Compound 2 was an approximately 22-40 fold stronger inhibitor than ASA on AA and U46619 induced aggregation (IC50: 1.6 and 15.6 microM, respectively).

PMID:
18704331
DOI:
10.1007/s12272-001-1242-1
[Indexed for MEDLINE]

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