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Stroke. 2009 Mar;40(3):e50-2. doi: 10.1161/STROKEAHA.108.525386. Epub 2008 Aug 14.

Good laboratory practice: preventing introduction of bias at the bench.

Author information

1
Centre for Clinical Brain Sciences, University of Edinburgh, UK.

Abstract

BACKGROUND AND PURPOSE:

As a research community, we have failed to demonstrate that drugs which show substantial efficacy in animal models of cerebral ischemia can also improve outcome in human stroke. Summary of Review- Accumulating evidence suggests this may be due, at least in part, to problems in the design, conduct and reporting of animal experiments which create a systematic bias resulting in the overstatement of neuroprotective efficacy.

CONCLUSIONS:

Here, we set out a series of measures to reduce bias in the design, conduct and reporting of animal experiments modeling human stroke.

PMID:
18703798
DOI:
10.1161/STROKEAHA.108.525386
[Indexed for MEDLINE]

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